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Frida Browning July 24, 2020 Anatomy

The use of the microscope in discovering minute, previously unknown features was pursued on a more systematic basis in the 18th century, but progress tended to be slow until technical improvements in the compound microscope itself, beginning in the 1830s with the gradual development of achromatic lenses, greatly increased that instrument’s resolving power. These technical advances enabled Matthias Jakob Schleiden and Theodor Schwann to recognize in 1838–39 that the cell is the fundamental unit of organization in all living things.

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This ancient discipline reached its culmination between 1500 and 1850, by which time its subject matter was firmly established. None of the world’s oldest civilizations dissected a human body, which most people regarded with superstitious awe and associated with the spirit of the departed soul. Beliefs in life after death and a disquieting uncertainty concerning the possibility of bodily resurrection further inhibited systematic study. Nevertheless, knowledge of the body was acquired by treating wounds, aiding in childbirth, and setting broken limbs. The field remained speculative rather than descriptive, though, until the achievements of the Alexandrian medical school and its foremost figure, Herophilus (flourished 300 bce), who dissected human cadavers and thus gave anatomy a considerable factual basis for the first time. Herophilus made many important discoveries and was followed by his younger contemporary Erasistratus, who is sometimes regarded as the founder of physiology.

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This is the result of humans having ancestors that began walking on their hind limbs rather than using all four limbs. Most of our anatomical insight was gained through the dissection of corpses (cadavers), and for a long time, it was the only way we could gain anatomical knowledge about the human body. It was a rather grotesque affair, but it made up the bulk of medical literature for centuries. These days, technological innovation has made it possible to explore human anatomy at a microscopic level.

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Humans have evolved separately from other animals, but since we share a distant common ancestor, we mostly have a body plan that is similar to other organisms, with just the muscles and bones in different proportions.

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When a body is dissected, its structures are cut apart in order to observe their physical attributes and their relationships to one another. Dissection is still used in medical schools, anatomy courses, and in pathology labs. In order to observe structures in living people, however, a number of imaging techniques have been developed. These techniques allow clinicians to visualize structures inside the living body such as a cancerous tumor or a fractured bone.

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The new application of magnifying glasses and compound microscopes to biological studies in the second half of the 17th century was the most important factor in the subsequent development of anatomical research. Primitive early microscopes enabled Marcello Malpighi to discover the system of tiny capillaries connecting the arterial and venous networks, Robert Hooke to first observe the small compartments in plants that he called “cells,” and Antonie van Leeuwenhoek to observe muscle fibres and spermatozoa. Thenceforth attention gradually shifted from the identification and understanding of bodily structures visible to the naked eye to those of microscopic size.

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