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Londyn Wolf July 6, 2020 Anatomy

The new application of magnifying glasses and compound microscopes to biological studies in the second half of the 17th century was the most important factor in the subsequent development of anatomical research. Primitive early microscopes enabled Marcello Malpighi to discover the system of tiny capillaries connecting the arterial and venous networks, Robert Hooke to first observe the small compartments in plants that he called “cells,” and Antonie van Leeuwenhoek to observe muscle fibres and spermatozoa. Thenceforth attention gradually shifted from the identification and understanding of bodily structures visible to the naked eye to those of microscopic size.

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By the end of the 19th century the confusion caused by the enormous number of names had become intolerable. Medical dictionaries sometimes listed as many as 20 synonyms for one name, and more than 50,000 names were in use throughout Europe.

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Form is closely related to function in all living things. For example, the thin flap of your eyelid can snap down to clear away dust particles and almost instantaneously slide back up to allow you to see again. At the microscopic level, the arrangement and function of the nerves and muscles that serve the eyelid allow for its quick action and retreat. At a smaller level of analysis, the function of these nerves and muscles likewise relies on the interactions of specific molecules and ions. Even the three-dimensional structure of certain molecules is essential to their function.

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The person who is trained to study human physiology is called a physiologist. Herman Boerhaave is referred to as the father of Physiology for his exemplary research and teaching during 1708.

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From Vesalius’s exact descriptions of the skeleton, muscles, blood vessels, nervous system, and digestive tract, his successors in Padua progressed to studies of the digestive glands and the urinary and reproductive systems. Hieronymus Fabricius, Gabriello Fallopius, and Bartolomeo Eustachio were among the most important Italian anatomists, and their detailed studies led to fundamental progress in the related field of physiology. William Harvey’s discovery of the circulation of the blood, for instance, was based partly on Fabricius’s detailed descriptions of the venous valves.

Thin sections and staining had become standard tools for microscopic anatomists by the late 19th century. The field of cytology, which is the study of cells, and that of histology, which is the study of tissue organization from the cellular level up, both arose in the 19th century with the data and techniques of microscopic anatomy as their basis.

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