Mariam Burris July 24, 2020 Anatomy
The new application of magnifying glasses and compound microscopes to biological studies in the second half of the 17th century was the most important factor in the subsequent development of anatomical research. Primitive early microscopes enabled Marcello Malpighi to discover the system of tiny capillaries connecting the arterial and venous networks, Robert Hooke to first observe the small compartments in plants that he called “cells,” and Antonie van Leeuwenhoek to observe muscle fibres and spermatozoa. Thenceforth attention gradually shifted from the identification and understanding of bodily structures visible to the naked eye to those of microscopic size.
Human anatomy is the scientific study of the body’s structures. In the past, anatomy has primarily been studied via observing injuries, and later by the dissection of anatomical structures of cadavers, but in the past century, computer-assisted imaging techniques have allowed clinicians to look inside the living body. Human physiology is the scientific study of the chemistry and physics of the structures of the body. Physiology explains how the structures of the body work together to maintain life. It is difficult to study structure (anatomy) without knowledge of function (physiology). The two disciplines are typically studied together because form and function are closely related in all living things.
For example, we might assume giraffes have more vertebrae in its neck than humans. No, despite being incredibly tall, giraffes have the same number of vertebrae, i.e. they also have seven vertebrae in their neck.
Like most scientific disciplines, anatomy has areas of specialization. Gross anatomy is the study of the larger structures of the body, those visible without the aid of magnification (Figure 1a). Macro- means “large,” thus, gross anatomy is also referred to as macroscopic anatomy.
This ancient discipline reached its culmination between 1500 and 1850, by which time its subject matter was firmly established. None of the world’s oldest civilizations dissected a human body, which most people regarded with superstitious awe and associated with the spirit of the departed soul. Beliefs in life after death and a disquieting uncertainty concerning the possibility of bodily resurrection further inhibited systematic study. Nevertheless, knowledge of the body was acquired by treating wounds, aiding in childbirth, and setting broken limbs. The field remained speculative rather than descriptive, though, until the achievements of the Alexandrian medical school and its foremost figure, Herophilus (flourished 300 bce), who dissected human cadavers and thus gave anatomy a considerable factual basis for the first time. Herophilus made many important discoveries and was followed by his younger contemporary Erasistratus, who is sometimes regarded as the founder of physiology.
Owing to church prohibitions against dissection, European medicine in the Middle Ages relied upon Galen’s mixture of fact and fancy rather than on direct observation for its anatomical knowledge, though some dissections were authorized for teaching purposes. In the early 16th century, the artist Leonardo da Vinci undertook his own dissections, and his beautiful and accurate anatomical drawings cleared the way for Flemish physician Andreas Vesalius to “restore” the science of anatomy with his monumental De humani corporis fabrica libri septem (1543; “The Seven Books on the Structure of the Human Body”), which was the first comprehensive and illustrated textbook of anatomy. As a professor at the University of Padua, Vesalius encouraged younger scientists to accept traditional anatomy only after verifying it themselves, and this more critical and questioning attitude broke Galen’s authority and placed anatomy on a firm foundation of observed fact and demonstration.
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